Institute of Applied sciences 1. INTRODUCTION Mankind lives in complex environment, and cooperates with other livings to survive in its environment. Domestic animals significantly play an immense role for human lives, and can serves as source of food, Money income and others (1). Despite positive impact of animals on human life, the interdependence between animals, human and environment can be an exposure to serious diseases disturbing public health as well as social economic and wellbeing of human population (2). The diseases transmitted from animals to humans are known as zoonoses and are transmitted through direct contacts or through water, food, and environmental conditions (3). the bacteria Ana-plasma phagocytophilum is an etiologic agent of Tick-borne fever which is an endemic disease of sheep and cattle in tick (Ixodesricinus) infested areas of Norway. This infection has been reported in humans and number of domestic animals as well as wild animals in the region (4). TBF diseases is fatal and it can be aggravated and complicated by second infections on the patient. TBF is a leading cause of suppressed immunity (5). Sheep living with this infection are vulnerable to secondary infections like tick pyaemia caused by Staphylococcus spp. And Pasteurella (Mannheimia) septicemia. Complications also include abortion in pregnant ewes, reduction of milk