Depletion of soil fertility is a main problem to sustain agricultural production and productivity in many countries. The use of inorganic or organic fertilizer alone has both positive and negative effects on plant growth, nutrient availability and the soil. Organic fertilizer improves physical and biological activities of soil but they have comparatively low in nutrient content, so larger quantity is required for plant growth. However, inorganic fertilizer is usually immediately and fast containing all necessary nutrients that are directly accessible for plants. But continuous use of inorganic fertilizers alone causes soil organic matter: degradation, soil acidity and environmental pollution. So the integrated nutrient management system is an alternative system for the sustainable and cost-effective management of soil fertility by combined apply of inorganic with organic materials resulting in rising soil fertility and productivity without affecting environment. The objective of the present review is to assess the effect of mixing organic with inorganic fertilizer on soil fertility and productivity. The study revealed that appropriate application of organic with inorganic fertilizers increases the productivity without negative effect on yield quality and improves soil fertility than the values obtained by organic or inorganic fertilizers separately.