No abstract

Highlights The diagnosis of primary malignant tumors is increasingly described with the improvement of life expectancy and the advent of new technologies. The management must be multidisciplinary and adapted to the condition of each patient. This entity affects elderly people with many comorbidities. Treatment should be the least aggressive and start with the most aggressive tumor. The elderly, a family history of neoplasia and smoking appear to be the factors favoring the appearance of multiple synchronous tumors. Our patient was an elderly person and a heavy smoker

Introduction: Androgen deprivation therapy is the mainstay of systemic treatment for metastatic prostate. However, the majority of patients progress to CRPC. The aim of this study is to identify factors that predict castration resistance in men with locally advanced or metastatic prostate cancer treated with first line ADT. Methods: This is a retrospective and analytical study including 46 patients treated for advanced or metastatic prostate cancer with first-line ADT at the Military Hospital Mohammed 5 of Rabat (HMMV) between November 2013 and July 2018 (a period of 5 years). The elements analyzed were sociodemographic, clinical, patient history, biological and radiological data. Results: Predictive factors for castration resistance in our sample are: 1) A high-risk stage according to the LATITUDE criteria. 2) High initial PSA. 3) PSA nadir (PSAn) > 1.17 ng/ml. 4) Elevated PAL at diagnosis > 129 IU/L. 5) Short time to reach PSAn ≤ 9 months. Conclusion: The risk factors predictive of early resistance to first-line hormonal therapy in patients with metastatic prostate cancer in our series were similar to those described in the literature. We advocate early treatment with hormonal chemotherapy in any patient with metastatic prostate cancer who has any of the elements identified in our study.

Summary: Glanzmann Thrombasthenia (GT) is a congenital thrombopathy characterised by bleeding manifestations that are sometimes severe. Treatment is based on platelet transfusions during bleeding. We report a case of TG revealed by haematuria and which presented a severe bleeding syndrome refractory to transfusions. Treatment with injections of recombinant activated factor VII was necessary. This case illustrates the value of using recombinant activated factor VII in TG in case of antiplatelet alloimmunisation or in case of lack of response to platelet transfusions.

Cancer of the penis is a relatively rare pathology in our country due to the widespread practice of circumcision. Easily diagnosed on the basis of a careful clinical examination and penile Magnetic resonance imaging (MRI), this cancer is often diagnosed late and poses a problem of management, particularly the acceptability of amputation of the penis. Partial penectomy is a surgical technique currently practised for cancers of the penis, when the indication arises, could be a form of conservative surgery allowing to have a good oncological result and to satisfy the request of the patient to try to preserve his erectile and sexual function. We report here a case of squamous cell carcinoma of the penis treated in our department by partial penectomy.