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A new antibiotic kazusamycin, was isolated from the culture broth of Streptomryces sp. No. 81-484, which shows antitumor activity against experimental marine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gramnegative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C;H,,O, (MW 556). In the course of a continuing search for novel antitumor antibiotics of microbial origin, kazusamycin was isolated from the fermentation culture of Streptomyces sp. No. 81-484. This paper describes the taxonomy of the producing organism, fermentation, isolation, and physico-chemical and biological properties of this antibiotic.

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