This study aims to examine the effect of technostress on job satisfaction by involving the role of burnout as a mediator and teamwork as a moderator. The population of this study is all Bank Indonesia employees. The selected sample is the employees who have been working more than two years and use information technology systems both software developed by BI and hardware such as smart phones and laptops. The sampling technique used is random sampling. The analysis uses Partial Least Square (PLS) as a statistical test technique. The result shows that technostress has a negative effect on job satisfaction, technostress has a positive effect on burnout, burnout has a negative effect on job satisfaction, burnout mediates the influence between technostress and job satisfaction, and teamwork moderates the effect of technostress and job satisfaction. These results figure that the higher psychological pressure faced by individuals due to the use of technology can reduce the level of individual job satisfaction. This result also means that individuals who experience psychological pressure due to the use of technology have an impact on increasing mental and psychological fatigue (burnout) of individuals. Mental and psychological fatigue cause individuals to be apathetic and reduce their level of satisfaction with the work done. But then, teamwork can reduce the negative effect of technostress on job satisfaction. These findings strenghten the previous theories especially the causality ones. It contributes to the realm of science especially in human resource management field, and can be a reference for practical managers especially in the Bank Indonesia as the research object. The originality lies in the combination of causality models, uses SEM-PLS as an analysis tool, and the new object. The limitation resides in the amount of variables that are only three, with one object