Objective: The objective of this study is to evaluate the profile of medicine usage in a Psychosocial Support Center type II (PSC), in the city of Jaboatão dos Guararapes-PE, Brazil. Methods: This is a retrospective cross-sectional descriptive study with a quantitative approach. The information obtained for the study came from the analysis of medical records of patients admitted to the institution from January to August 2015. A total of 157 medical records were analyzed, observing to sociodemographic, clinical and medication use variables. Results: There was a predominance of female patients, 57.25% (male 42.75%). Most of the participants were single, with incomplete elementary education, aged between 30-39 years. Most of them had previously been admitted to psychiatric hospitals. From the total number of users who reached the PSC, 60.5% were referred by the Psychosocial Care Network. The most frequent diagnoses, according to the International Statistical Classification of Diseases and Related Health Problems (ICD), were: schizophrenia, schizotypic disorders and delusional disorders (F20 to F29), and affective mood disorders (F30-F39). It was found that 99.4% of patients used at least 1 medication, which was used twice daily (59.6%). The most prescribed class of drugs was the antipsychotics, mainly chlorpromazine, haloperidol and risperidone. From the total prescribed drugs, 83.3% were in accordance with the Brazilian Common Denomination 85% of them were present in the municipal list of essential drugs and 97% were administered orally. Conclusion: The results found in this study were satisfactory. Thus, it was possible to verify that the medicines are great allies in the psychosocial treatment, presenting as a widely-used resource.