In this work, the efficiency of partially hydrophobized hyperbranched polyglycerols (HPG11 and HPG12) as cetyltrimethylammonium bromide (CTAB) carriers was evaluated to prevent surfactant losses by adsorption on reservoir rocks surface during enhanced oil recovery (EOR) processes. Interactions between surfactant and polymers were studied by conductivity, zeta potential, and particle size measurements showing that complexes were formed between the components. The ability of PG, HPG11, HPG12 and those complexes to reduce the interfacial tension (IFT) was verified and one of the complexes was able to reduce the IFT to values under 1.0 mN/m, suggesting the occurrence of a synergy between the components. Molecular dynamics simulations indicated the preferential sites of interaction between surfactants and HPGs. HPG11:CTAB and HPG12:CTAB complexes' ability to permeate an unconsolidated porous medium and deliver the surfactant at the water–oil interface, increasing oil production, was evaluated through transport and oil displacement tests, and the results showed that the HPG12:CTAB complex led to almost 90% of oil recovery.