The objective was to evaluate the effect of enzymes on consumption, digestion of dry matter and blood nutrients and metabolites. Sixteen lambs with an average age and weight of 3 months and 19.00 kg, respectively, were used. Treatments consist of the use of amylolytic, proteolytic and fibrolytic enzymes. A completely randomized design was used. No differences (P>0.05) were found for intake and digestion of dry matter and nutrients. There was a statistical difference (P<0.05) for the urea variable, where treatment Amaize® and Amaize® + Fibrozyme® were thought to be superior to the others. It can be concluded that the inclusion of amylolytic enzymes associated with proteolytic enzymes does not cause any effects to the animals, and deleterious effects can be added to the feed of lambs.