Objective: This retrospective study aimed to assess the risk factors associated with early implant failure using a multivariate logistic regressive model and generalized evaluating equations (GEE) analysis. A total of 892 patients who received 1931 dental implants within the period from 2015 to 2018 at Odonto-Maxillo-Facial Hospital, Ho Chi Minh City, Vietnam were included in this study. Several factors as age, gender, implant placement site, implant length and diameter, sinus lifting technique, the number of implants per patient, and implant brands were recorded. GEE analysis results showed that the implant-based failure rates were 6.1% after an observation period from 3 months to 3 years. Among 118 failed implants, 108 implants were lost before or at the abutment connection stage (91.5%). Male, maxilla implant placement and implant brands were identified as the risk factors for early implant loss. Implant brands which have significantly less early failure rates are Ritter, Nobel, MIS, Osstem, Neo.