A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-yliminomethyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity.

Two new Pd(II) complexes have been prepared from 2-methyl 4-amino quinoline and [PdCl2(EPh3)2] (E = P or As). The complexes, [PdCl2(L)(PPh3)] and [PdCl2(L)(AsPh3)] were characterized by elemental analysis, NMR, IR and UV-Vis absorption spectroscopy and single crystal X-ray diffraction. The binding affinity and the binding mode of the ligand and the complexes toward CT-DNA/BSA were determined by spectrophotometric titrations and strong interaction of the complexes with CT-DNA and BSA has been observed. An in vitro cytotoxicity study of the compounds against human lung (A-549) and breast (MCF-7) cancer cell lines gave IC50 values for both the ligand and the two complexes in the range of Cisplatin and Doxorubicin.

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Two new Pd(II) complexes of N′‐(4‐(diethylamino)‐2‐hydroxybenzylidene)furan‐2‐carbohydrazide were synthesized and characterized using various spectral methods. The structure of one of the complexes was determined using single‐crystal X‐ray diffraction. DNA and protein binding affinities of the synthesized compounds were examined using UV–visible and fluorescence titration method. In addition, the in vitro cytotoxicity of the compounds was evaluated against A549 (lung cancer) and MCF7 (breast cancer) cell lines using the MTT assay method.

A water soluble chloro bridged binuclear copper(II) complex (3) and mononuclear complex (4) have been synthesized from chloro substituted 2‐oxo‐1,2‐dihydroquinolin‐3‐yl‐methylene‐2 hydroxybenzohydrazide 1 and 2 and CuCl2·2H2O. The structures of the complexes have been determined by single crystal X‐ray diffraction. The binding interactions of the ligands and complexes with CT‐DNA and protein have been evaluated by absorption and emission spectroscopic method. CT‐DNA and ethidium bromide (EB) competitive studies revealed that the compounds could interact with CT‐DNA through intercalation binding mode. Interactions of the compounds with BSA were also studied by UV−visible, fluorescence and synchronous fluorescence spectroscopic methods which showed that the compounds had a strong binding affinity with BSA through static quenching process. The cytotoxic effect of the compounds examined on cancer cell lines, such as A549 (lung cancer) and MCF7 (breast cancer) cell lines showed that all four compounds exhibited substantial cytotoxic activity.