The capability in holding the activities of α-glucosidase (1U/mL) of crude extract and mitragynine from Mitragyna speciosa Korth 10 mg/mL. Crude ethyl acetate extracts 61.52±0.47% (IC50 = 17.28 mg/mL) which closed to acarbose 78.94±2.97% (IC50  = 15.74 mg/mL). Minimum density acarbose 0.1562 mg/mL, 4.95±5.96%, crude hexane extracts 2.5 mg/mL, 0.78±11.52%, crude dichloromethane extracts 2.5 mg/mL, 4.40±7.73%, crude ethyl acetate extracts 0.3125 mg/mL, 0.51±5.20 %, crude ethanol extracts 1.25 mg/mL, 0.29±2.54%, crude methanol extracts 0.625 mg/mL, 0.71±0.49%, fractions c (Mitragynine) 5 mg/mL, 1.54±4.50%, crude water extracts, fractions a and b, it was found that there was no activity holding of glucosidase enzyme which meant that korth had the ability to hold the activity of α-glucosidase enzyme in extracting by ethyl acetate. It was also another treatment option and to reduce adverse effects from medication in patients with type 2 diabetes. According to research, the effects of consuming korth leaves should be cautious. Studies on the neuroprotective effects of mitragynine showed that mitragynine could stimulate the nervous system just like cocaine, thereby causing nausea and vomiting. Additionally, korth leaf extract had been reported to be toxic to the liver and kidneys.