The formation of amide bonds is one of the most stimulating emerging areas in organic and medicinal chemistry.A mides are recognized as central building blocks in a plethora of interesting pharmaceuticals, proteins, peptides, polymers, naturalp roducts, functional materials, andb iologically relevant carbocyclic or heterocyclic molecules, and they are also found in av ariety of industrial fields. Therefore, a review of recent developments and challenges in the formation of amide bonds from carbonyl compounds is particular-ly important. Herein, we have scrutinized ar ange of metalcatalyzed andm etal-free approaches for the synthesis of amides from aldehydes, ketones, and oximes. In addition, this Minireview highlightsr elevant mechanistic studies, as well as the potential applications of these methods in the synthesis of candidate drug molecules. We hope that the data compiled herein will encourage further progress in this notable area of chemistry research.

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