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Many of the topics briefly addressed in this article are discussed more extensively in this issue of Clinical and Translational Molecular Imaging by distinguished colleagues from all fields related to the care of differentiated thyroid cancer (DTC) patients. Several open issues in the management of DTC are fueled by the progress that has been made in the past decade, which is an indication of the liveliness of this scientific field. Aside from some remarkable results achieved in basic and clinical research, the greatest improvements and achievements in this field in recent years concern truly multidisciplinary research and patient-oriented guidelines. These should pave the way for future initiatives to build on the advances achieved in DTC care in the recent past.

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