Objective: To describe of quality of life among patients with chronic urticaria at the Department of Allergy, Immunology and Dermatology at E Hospital in 2022. Participants and methods: A cross-sectional descriptive study was conducted on 95 patients with chronic urticaria at the Department of Allergy, Immunology and Dermatology, Hospital E. The questionnaire to assess the quality of life of patients with chronic urticaria was developed by the researcher based on the CU - Q2oL questionnaire. Results: The overall mean score on quality of life of the patients was calculated as 64.36 ± 12.44 (37-102) points. The average score of problems affecting the quality of life of patients with chronic urticaria were itching 1.95/4 points; swelling 1.97/4 points; daily activities 1.9/4 points; sleep 2.01/4 points; limitation 1.85/4 points and appearance 2.0/4 points. Conclusion: The quality of life of patients with chronic urticaria is significantly low. Nurses need to provide health education about nutrition, exercise, and choose appropriate cosmetics and clothing.