Background: Indication for treatment of intermediate coronary artery lesions is wavering. Worldwide studies showed the role of FFR in guiding the treatment for these cases. Objective: To study the outcomes of FFR-guided PCI in intermediate coronary artery lesions. Method: Cohort study with comparative analysis of 12-month MACE between two groups: Medical treatment with FFR > 0.8 and PCI with FFR ≤ 0.8. Results: 40 stenosis lesions with FFR ≤ 0.8 (57.14%) was treated by PCI and 30 stenosis lesions with FFR > 0.8 treated by medical therapy. The percentage stenotic diameter cut-off was >55.62% on QCA with Sp 60% and Se 75%. There was no significant difference in MACE between two groups after 12-month follow-up. Conclusions: FFR has important role in guiding treatment for intermediate coronary artery lesions. Key words: ffR-guided, coronary arery