IMPORTANCEOlder patients and those with comorbidities who are infected with SARS-CoV-2 may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody for the treatment of high-risk patients to prevent COVID-19 progression.OBJECTIVE To evaluate the efficacy and adverse events of sotrovimab in preventing progression of mild to moderate COVID-19 to severe disease.DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial including 1057 nonhospitalized patients with symptomatic, mild to moderate COVID-19 and at least 1 risk factor for progression conducted at 57 sites in Brazil, Canada,

Abstract-Traditional approaches to transmit information reliably over an error-prone network employ either Forward Error Correction (FEC) or retransmission techniques. In this paper we consider an application of network coding to increase the bandwidth efficiency of reliable broadcast in a wireless network. In particular, we propose two schemes which employ network coding to reduce the number of retransmissions as a result of packet losses. Our proposed schemes combine different lost packets from different receivers in such a way that multiple receivers are able to recover their lost packets with one transmission by the source. The advantages of the proposed schemes over the traditional wireless broadcast are shown through simulations and theoretical analysis. Specifically, we provide a few results on the retransmission overhead of the proposed schemes under different channel conditions.

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Abstract-Packet loss and end-to-end delay limit delay sensitive applications over the best effort packet switched networks such as the Internet. In our previous work, we have shown that substantial reduction in packet loss can be achieved by sending packets at appropriate sending rates to a receiver from multiple senders, using disjoint paths, and by protecting packets with forward error correction. In this paper, we propose a Path Diversity with Forward error correction (PDF) system for delay sensitive applications over the Internet in which, disjoint paths from a sender to a receiver are created using a collection of relay nodes. We propose a scalable, heuristic scheme for selecting a redundant path between a sender and a receiver, and show that substantial reduction in packet loss can be achieved by dividing packets between the default path and the redundant path. NS simulations are used to verify the effectiveness of PDF system.

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