The public debate about the right type of agriculture for Sub-Saharan Africa (SSA) often constructs a dichotomy between smallholders and large-scale agriculture. This oversimplification ignores some important intermediary forms for organising agriculture, including nucleus-outgrower schemes (NOSs). NOSs promise to combine the benefits of both while potentially reducing, though not avoiding, (part of) their drawbacks. This article analyses the conditions under which NOSs are feasible and beneficial for investors, outgrowers and rural development for selected value chains in Tanzania. It is based on an empirical study comprising 276 qualitative interviews with various stakeholders conducted in central Tanzania in spring 2015 on 10 NOSs in three subsectors (rice, sugar cane and tea) in different stages of realisation (planning, establishment, full production and failure or near-failure). The study examines why investments succeed or fail in different stages, the socioeconomic impacts and various policies important for their fate. Findings show that there are many challenges to successfully implementing NOSs in Tanzania, including national policies on the business environment, on agriculture in general and on specific subsectors, and, especially, on land issues. Nevertheless, these schemes seem to have considerable potential to support local development, particularly by providing employment and salaries, incomes for outgrower farmers, infrastructure and corporate social responsibility (CSR) projects as compensation for loss of access to land for the community. The specific details of a particular business model influence the opportunities and risks, but no single model seems to be superior; much depends on the subsector structure and the services already available. In general, policies to attract and steer NOSs in Tanzania are not yet sufficiently developed, coordinated or implemented.