Summary Gapsplit generates random samples from convex and non-convex constraint-based models by targeting under-sampled regions of the solution space. Gapsplit provides uniform coverage of linear, mixed-integer and general non-linear models. Availability and implementation Python and Matlab source code are freely available at http://jensenlab.net/tools. Supplementary information Supplementary data are available at Bioinformatics online.

generates random samples from convex and non-convex constraintbased models.targets under-sampled regions of the solution space for uniform coverage.Availability and Implementation: Python and Matlab source code are freely available at http://jensenlab.net/tools.