Background: To date, there are no studies evaluating the use of the titanium-nitride-oxide coated stent in patients with multivessel coronary artery disease. We have compared the performance of the Titan-2 ® stent to that of the second generation drug-eluting stents in this scenario. Methods: From 2011 to 2012, 284 patients were treated with the Titan-2 ® stent, of which 100 (35.2%) had multivessel coronary artery disease. This group was compared to 100 patients, of a group of 304 (38.9%) patients with multivessel coronary artery disease treated with second generation drug-eluting stents with durable or biodegradable polymers. The primary endpoint was the occurrence of major adverse cardiovascular events at 1 year. Results: Clinical, angiographic and procedure-related characteristics of the patients did not show differences between groups. Most patients in the Titan-2 ® group were male (70%), mean age was 68.4 ± 12.9 years and 25% were diabetic. Stable symptomatic patients were prevalent (68%), 51% had three-vessel disease and ventricular function was preserved (55.6 ± 12.7%). The incidence of major adverse cardiovascular events at 1 year in the Titan-2 ® group was 21% (vs. 17%; p = 0.59), death was observed in 3% (vs. 2%; p > 0.99) of the patients, acute myocardial infarction in 5% (vs. 4%; p > 0.99) and a new revascularization procedure in 13% (vs. 11%; p = 0.83). Definitive stent thrombosis was not observed in either group. Conclusions: The Titan-2 ® stent showed similar results to those of the second-generation drug-eluting stents, which makes it attractive for use in the complex scenario of patients with multivessel coronary artery disease.

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Objective: To confirm the validity of the calculation in MVA applying the method of Doppler pressure half-time directly in left atrial (LA) and pulmonary capillary pressure curve. Methods:Thirty-five patients with mitral valve stenosis underwent percutaneous mitral valvotomy (PMV) using the Cribier method with MVA measurement made using the traditional methods (Gorlin and echo-Doppler) and this propose. MVA values obtained were compared and a linear regression model was used to obtain formula for reciprocal calculations of the mitral valve area.Results: A statistically correlation was found between the calculated values by all methods. The proposed method showed a strong correlation (p< 0.05) with the others mainly before valve opening. Simple reciprocal calculation formulas were found for mitral valve area assessment. Conclusions:The proposed method for the calculation of mitral valve area using LA or Cap proved to be highly accurate and simple making it possible to safely monitor valvotomy procedures.Key words: Pressure half-time, mitral valve area by half-pressure, left atrium of the half-pressure.