Introduction: Periimplantitis is a disease most commonly affecting dental implants placed in patients with a history of periodontal disease. It is still questionable if native bone is more resistant to periimplantitis than regenerated bone. Case presentation: A case of dental implant placed in regenerated bone in a patient with treated periodontal disease is presented. The patient is a male healthy adult, who lost the tooth #11 due to advanced periodontal disease. 4 weeks after tooth extraction, the alveolar ridge was augmented and the dental implant was placed 5 months after the guided bone regeneration. The dental implant was restored 3 months after placement. The patient was compliant with the periodontal recall appointments for 2 years. After a personal crisis, the patient neglected his oral hygiene and failed to follow his periodontal recall visits for 7 years. When he finally presented for a dental examination, the dental implant #11 showed significant bone loss and periodontal tissue inflammation. The site was treated conservatively and surgically treated and augmented-with a combination of xenograft, allograft and a collagen membrane-in order to achieve re-osseintegration. Conclusions: Patients with periodontal disease are at high risk for peri-implantitis. Regular recall visits are essential for maintenance of dental tooth and implant health, since treatment of peri-implantitis is a very demanding procedure.