Starting with the proposition that a generalized fear of uncertainty is the psychological variable which accounts for the organization of social attitudes along a general factor of liberalism-conservatism, it was hypothesized that conservatives would express an aversion to highly complex and abstract art works. Twenty paintings were chosen by an art expert, five to represent each of four categories differing in degree of uncertainty: simple representational, simple abstract, complex representational, and complex abstract. As predicted, high scorers on the Conservatism Scale preferred paintings in the simple representational category and showed a definite dislike of the complex representational and complex abstract works, while liberals preferred the more complex and abstract paintings. It was further demonstrated that the complexity dimension was the primary discriminator of the judgments of liberals and conservatives (r-.S6, p < .01) rather than abstraction (r=-.14, ns).

A series of 14 vinylureidopenicillins and a series of 9 ureidopenicillins were prepared by reaction of 6-aminopenicillanic acid with vinyl isocyanates and isocyanates. These compounds were evaluated for their potential to protect ruminants against lactic acidosis. The compounds were tested for inhibition of in vitro ruminal lactic and propionic acid production, and six compounds inhibited lactic acid production to less than 10% of control at doses of 0.31 microgram/mL or lower, whereas they did not inhibit propionic acid production at doses greater than 10 micrograms/mL. The most active compounds also were screened for general antibacterial activity and were found to be weakly active against Gram-positive bacteria. The structure--activity relationships are discussed for both series. Triethylammonium 6-[3[2-(4-tert-butylphenyl)vinyl]ureido]penicillanate (4) was chosen for evaluation as an inhibitor of intraruminal lactic acidosis in vivo.

Aus den Acrylsäurechloriden (I) erhält man die Isocyanate (II), die zu den Penicillinen (III) umgesetzt werden.