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The double bond of dodecenoic acid in the endotoxin-antagonistically acting lipid A of Rhodobacter capsulatus, strains 37b4 and St Louis, was found to have cis-configuration. The position of the double bond was ω7. The mono-unsaturated fatty acids of lipid A from a number of additionally investigated strains of various species of the α-, β-, and γ-subgroups of Proteobacteria (Agrobacterium spp., Azospirillum spp., Rhizobium meliloti, Rhodobacter sphaeroides, Rhodomicrobium vannielii, Rhodopseudomonas blastica, Rhodospirillum salinarum, Sphaerotilus natans, Thiobacillus spp. and Yersinia enterocolitica) have also cis -configuration with the double bond in the ω7-position (one exception), suggesting the anaerobic pathway of biosynthesis to be common for most of them.