This article focuses on the development of science and technology as manifested in the four industrial revolutions in the modern era, highlighting their ethical implications and challenges against the background of the Christian, monotheistic (metanarrative) framework. It explores the relationship between Christian theology of creation, scientific development, and Western secularization, offering critical assessments about what the global world has come to call »Industrial Revolution 4.0« (IR 4.0, as of the 2010s) and the new ethical dilemmas that IR 4.0 presents to us. While the starting point of our reflection is Western intellectual tradition, authors hope to bring a global perspective on the issue with concrete impulses for further theological/ethical reflection and education.