Background & Aims-5-FU-based adjuvant chemotherapy does not increase survival times of patients with colorectal tumors with microsatellite instability. We determined the response of patients with colorectal tumors with the CpG island methylator phenotype (CIMP) to 5-FU-based therapy.

Background & Aims-Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary non-polyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair (MMR) gene mutations that define this syndrome and result in microsatellite instability. The carcinogenic pathways and the best diagnostic approaches to detect microsatellite stable (MSS) HNPCC tumors are unclear. We investigated the contribution of epigenetic alterations to development of MSS HNPCC tumors.

Climate change has led to the rise of a sustainable development area characterized by the consumers' consideration of social and environmental issues. The existing literature on responsible consumption has essentially explored the context of western countries; however, little information is given around the consumer behavior towards green products in developing countries. This study enriches this literature by exploring the context of Vietnam that was heavily affected by climate changes.More precisely, the authors aim to explore the content of green products from the consumers' point of view, as well as their motivations and barriers to consume ecofriendly products. A qualitative study conducted with 29 Vietnamese respondents showed that consumers associate green products to five dimensions: environment, health, quality, price, and animal welfare. They express essentially egoistic motivations related to health and product's quality. In addition, the main barriers to purchase green products identified in the study correspond to the lack of information and confidence towards green claims, sellers, and certifications.Note. PCE: perceived consumer effectiveness.