Mesoporous Mn-Se/Al 2 O 3 could be easily fabricated by calcining the selenium sources with the manganese and aluminum hydroxides. It was an efficient catalyst for alcohol oxidation using H 2 O 2 as the clean oxidant, affording carbonyls in 58%-83% yields. The reaction of primary alcohols could produce aldehydes specifically, while no carboxylic acids were generated. The easily accessible features and low cost of Mn-Se/Al 2 O 3 may endow the material great potential in the industrial-scale applications.