Palladium-catalyzed asymmetric C–H functionalization to yield axially chiral styrene-type carboxylic acids is described, in which axial chirality and sterically hindered group were incorporated in one-step.
As an alternative approach to traditional C-H activation that often confined to harsh conditions, vicinal or primary C-H functionalization, radical relay offers a solution to these long-held problems. Enabled by...
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