Multiple myeloma (MM) is the second most common malignancy in hematology. MM is characterized by the malignant proliferation of plasma cells in the bone marrow, accompanied by the secretion of monoclonal immunoglobulin, mainly occurring in the elderly. The clinical manifestations of MM include renal dysfunction, bone destruction, infection, anemia, hemorrhage, hypercalcemia, and hyperviscosity syndrome. The recent discovery of biomarkers related to the diagnosis or prognosis of MM provides an important basis for the diagnosis and treatment of MM. This paper reviews the research progress of biomarkers expressed in tissues and peripheral blood at home and abroad.

Objective: To investigate the effect of small nucleolar host gene 12 (SNHG12) on the migration and invasion of human lung cancer cells by regulating human angiostatin binding protein through microribonucleic acid (microRNA)-497. Methods: A549, H1299, and PC9 cells were cultured in Roswell Park Memorial Institute (RPMI)-1640 medium containing 10% fetal bovine serum, and human bronchial epithelial (HBE) cells were cultured in Dulbecco’s modified eagle medium (DMEM) containing 10% fetal bovine serum. The incubator conditions were as follows: saturated humidity, 37?, and 5% carbon dioxide (CO2). Results: The gene expressions of small nucleolar host gene 12 (SNHG12) in HBE, A549, H1299, and PC9 were 1.00 ± 0.02, 5.61 ± 0.42, 3.78 ± 0.29, and 3.51 ± 0.23, respectively. The gene expressions of microRNA-497HBE, A549, H1299, and PC9 were 1.00 ± 0.13, 0.21 ± 0.04, 0.35 ± 0.05, and 0.37 ± 0.06, respectively, with P < 0.05. The microRNA-497 gene expression and cell apoptosis rate in the microRNA-497 group and the microRNA-497 + pcDNA3.1 group were significantly higher than those in the miR-NC group, whereas the A value and cell invasion number were significantly lower than those in the miR-negative control (NC) group, with P < 0.05. Compared with the microRNA-497 + pcDNA3.1 group, the microRNA-497 gene expression and cell apoptosis rate in the microRNA-497 + SNHG12 group were significantly lower, whereas the A value and cell invasion number were significantly higher, with P < 0.05. Conclusion: SNHG12 can inhibit the migration and invasion of human lung cancer cells by regulating human angiostatin binding protein through microRNA-497.