Laboratory equipment planning is a very important task in modern enterprise management. Laboratory equipment planning by computer algorithm is a very complex NP-hard combinatorial optimization problem, so it is impossible to find an accurate algorithm in polynomial time. In this study, an improved genetic algorithm is used to solve and analyze the comprehensive planning of laboratory equipment. After analyzing the traditional heuristic algorithm and genetic algorithm to solve the simple laboratory equipment planning problem, the simple laboratory equipment planning is designed and implemented according to the principle of the heuristic algorithm. Finally, the algorithm is implemented in Python. A general equipment planning based on genetic algorithm with two selection operators is realized. Two constraints of test start and completion time are given. In the scenario of using multiple test equipment for a test project, the possible solutions of laboratory equipment planning under given constraints are analyzed. The efficiency coefficient is not necessarily a constant, it is related to the output characteristics of energy equipment. Three independent planning algorithms are used to solve the actual test requirements. One is the planning method based on manual test scheduling in the test cycle of experimental instruments, the other is the genetic algorithm for gene location crossover operator, and the third is the genetic algorithm for experimental part crossover operator. The planning solutions obtained by the three algorithms are compared from three aspects: the shortest time to complete the test, the calculation time of the algorithm, and the utilization of the test equipment.