The mobile screening of digital movies can fully take into account the viewing experience of scattered areas. As a public cultural service system, it is playing a pivotal role. The consistency of the film screened with the tastes of the audience in the service area of the screening team has largely affected the quality of rural public culture services. Traditional recommendation algorithms directly use raw data to make predictions, leading to deviations in predictions. This article draws on the principles of immune recognition, clone selection, immune mutation, and self-adaptation of the artificial immune system to improve the recommendation effect of single-type data, the recommendation effect of sparse data, and the recommendation effect of project cold start problems and discusses the recommendation based on artificial immunity. For the single type of data, there are only positive samples, which leads to the problem that the training results are all positive. This paper proposes a single-class recommendation algorithm based on artificial immunity. The algorithm uses the positive and negative sample addition method proposed in this paper to add positive and negative samples related to user selection, so as to effectively solve the problem of difficult definition of data negative samples. Then, the artificial immune network is used to cluster the users of various activities, reduce the size of the candidate neighbor set, calculate the user’s nearest neighbor set, and give recommendations.