Mobile devices nowadays have penetrated our daily life and they play a big role in our social, professional, and recreational activities. In order to satisfy the booming demands for mobile communications from their customers, the telecommunication service provides work very hard to secure more spectrum and construct more base-stations. As such, they have looked into unlicensed spectrum for possible deployment of their mobile services. Toward this end, this paper presents a time-domain interference cancellation (TDIC) receiver technique that can enhance the efficiency of mobile communication networks coexisting with Wi-Fi traffic in the unlicensed bands. Moreover, transmitter power control and novel channel estimation are proposed to optimize the overall throughput of the fourth-generation mobile communication networks operating in the unlicensed bands (LTE-U). We further show by simulation and by over-the-air (OTA) real-time demonstration that the proposed solution indeed can achieve reliable reception of LTE-U signals under Wi-Fi interferences with different power levels.