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The Goldcorp High-Grade zone at the Red Lake mine has reserves (proven and probable) established at 1.775 million tons (Mt) at an average grade of 80.6 g/t Au. New U-Pb geochronologic data combined with detailed mapping and crosscutting relationships provide timing constraints and new insights into the formation of the exceptionally rich Goldcorp High-Grade zone. The results show that the main stage of the high-grade mineralization in the High-Grade zone formed before 2712 Ma and that a second stage of gold mineralization, much smaller in terms of total gold content but spectacular in terms of grade, formed after 2702 Ma. This second stage is attributed to gold remobilization caused by the enhanced thermal gradient and deformation associated with the emplacement of the Cat Island pluton (2699 Ma), approximately 7 km east of the deposit, or by the ca. 2.63 to 2.66 Ga postorogenic regional thermal event indicated by hornblende, muscovite, and biotite Ar-Ar cooling ages from the Uchi subprovince. It is proposed that the main stage of high-grade mineralization formed between ca. 2723 to 2712 Ma, possibly synchronous with emplacement of the Dome and McKenzie Island stocks, the Abino granodiorite, and Hammell Lake batholith, as well as with penetrative D 2 main-stage regional deformation.