The spread of demand-response (DR) programs in Europe is a slow but steady process to optimize the use of renewable energy in different sectors including manufacturing. A demand-response program promotes changes of electricity consumption patterns at the end consumer side to match the availability of renewable energy sources through price changes or incentives. This research develops a system that aims to engage manufacturing power consumers through price- and incentive-based DR programs. The system works on data from heterogeneous systems at both supply and demand sides, which are linked through a semantic middleware, instead of centralized data integration. An ontology is used as the integration information model of the semantic middleware. This chapter explains the concept of constructing the ontology by utilizing relational database to ontology mapping techniques, reusing existing ontologies such as OpenADR, SSN, SAREF, etc., and applying ontology alignment methods. Machine learning approaches are developed to forecast both the power generated from renewable energy sources and the power demanded by manufacturing consumers based on their processes. The forecasts are the groundworks to calculate the dynamic electricity price introduced for the DR program. This chapter presents different neural network architectures and compares the experiment results. We compare the results of Deep Neural Network (DNN), Long Short-Term Memory Network (LSTM), Convolutional Neural Network (CNN), and Hybrid architectures. This chapter focuses on the initial phase of the research where we focus on the ontology development method and machine learning experiments using power generation datasets.