A series of novel substituted‐[1,2,4]oxadiazolo[5,4‐d][1,5]benzothiazepine derivatives contain quinoline ring 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l were synthesized by the reaction of benzothiazepines 4a, 4b, 4c and substituted‐benzohydroximinoyl chlorides through the 1,3‐dipolar cycloaddition reaction in the presence of Et3N at room temperature. The structures of the obtained adducts were elucidated by MS, IR, 1H NMR, and elemental analyses. In addition, the structures of 5e were further confirmed by X‐ray single crystal diffraction study.

A series of novel 1,2,4‐oxadiazoline derivatives containing 2‐(1,2,4‐triazol‐1‐yl)quinoline were synthesized by the reaction of imines with benzohydroximinoyl chlorides in the presence of Et3N via 1,3‐diplolar cycloaddition reaction. The structures of the target compounds were confirmed by IR, 1H NMR, MS, elemental, and X‐ray crystallographic analysis.

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A series of novel pyrazolyl‐oxadiazoline derivatives bearing 1,2,4‐triazole moiety 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o, 4p were synthesized by schiff bases of 3‐methyl‐1‐phenyl−5‐(1,2,4‐triazole‐1‐yl)‐4‐formylpyrazole 3a, 3b, 3c, 3d and various benzohydroximinoyl chlorides in the presence of Et3N via 1,3‐dipolar cycloaddition reaction. The target products were confirmed by IR, 1H‐NMR, MS, elemental analysis. In addition, the structure of compound 4d was defined by X‐ray crystallography.

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