Poly(acrylonitrile-co-vinyl acetate) (PAN-VA) is utilized as a gelation agent to prepare gel-state electrolytes for dye-sensitized solar cell (DSSC) applications. Based on the synergistic effect of PAN-VA and TiO(2) fillers in the electrolyte, the gel-state DSSC can achieve a conversion efficiency higher than that of a liquid counterpart. The high performance of the gel-electrolyte is attributed to the in situ gelation property of the gel-electrolyte, the contribution of the PAN-VA to the charge transfer, as well as the enhancement effect of TiO(2) fillers on the charge transfer at the Pt-electrolyte interface. The experimental results show that the efficiencies of the gel-state cells have little dependence on the conductivity of the electrolytes with various contents of PAN-VA, but are closely related to the penetration situation of the electrolyte in the TiO(2) film. For PAN-VA concentrations ≤15 wt%, the electrolyte can be easily injected at room temperature based on its in situ gelation property. For higher PAN-VA concentrations, good penetration of the high viscous electrolyte can be achieved by elevating the operation temperature. By utilizing a heteroleptic ruthenium dye (coded CYC-B11), gel-state DSSCs with an efficiency of above 10% are obtained. Acceleration tests show that the cell is stable under one-sun illumination at 60 °C.

A new style of resistance exercise using elastic bands with four color combinations (yellow-red, red-red, red-green, and green-green) over a period of 8 weeks can significantly improve lower-extremity function among females with mild-to-moderate knee OA.

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Polo-like kinase 1 (PLK1), a critical cell cycle regulator, has been identified as a potential target in osteosarcoma (OS). 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2), a prostaglandin derivative, has shown its anti-tumor activity by inducing apoptosis through reactive oxygen species (ROS)-mediated inactivation of v-akt, a murine thymoma viral oncogene homolog, (AKT) in cancer cells. In the study analyzing its effects on arthritis, 15d-PGJ2 mediated shear-induced chondrocyte apoptosis via protein kinase A (PKA)-dependent regulation of PLK1. In this study, the cytotoxic effect and mechanism underlying 15d-PGJ2 effects against OS were explored using OS cell lines. 15d-PGJ2 induced significant G2/M arrest, and exerted time- and dose-dependent cytotoxic effects against all OS cell lines. Western blot analysis showed that both AKT and PKA-PLK1 were down-regulated in OS cell lines after treatment with 15d-PGJ2. In addition, transfection of constitutively active AKT or PLK1 partially rescued cells from 15d-PGJ2-induced apoptosis, suggesting crucial roles for both pathways in the anti-cancer effects of 15d-PGJ2. Moreover, ROS generation was found treatment with 15d-PGJ2, and its cytotoxic effect could be reversed with N-acetyl-l-cysteine. Furthermore, inhibition of JNK partially rescued 15d-PGJ2 cytotoxicity. Thus, ROS-mediated JNK activation may contribute to apoptosis through down-regulation of the p-Akt and PKA-PLK1 pathways. 15d-PGJ2 is a potential therapeutic agent for OS, exerting cytotoxicity mediated through both AKT and PKA-PLK1 inhibition, and these results form the basis for further analysis of its role in animal studies and clinical applications.