Carcinosarcoma of the esophagus is a rare neoplasm with both carcinomatous and sarcomatous components. This study aimed to investigate its clinicopathologic features and endoscopic characteristics. The data of patients diagnosed to have esophageal carcinosarcoma pathologically in the past 30 years (January 1976-December 2007) were reviewed. Of 3318 cases of esophageal malignancy, 12 were diagnosed as esophageal carcinosarcoma, with an incidence of 0.36%. All of the cases were male with a mean age of 62.3 years. Of the 12 tumors, 8 were polypoid type, and 4 were ulcerative type. In the endoscopic ultrasonography examination, the tumors show heterogeneous hypoechoic lesions with irregular outer margins and internal multicystic components. Four patients (33.3%) had previous head and neck squamous cell carcinoma that occurred metachronously. This is the first report about the characteristics of esophageal carcinosarcoma under endoscopic ultrasonography examination. The relationship between esophageal carcinosarcomas and head and neck cancer needs further investigation.

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The beam splitter is one of the important elements in optical waveguide circuits. To improve the performance of an optofluidic beam splitter, a microchannel including a two-stage main channel with divergent side walls and two pairs of inlet channels is proposed. Besides, the height of the inlets injected with cladding fluid is set to be less than the height of other parts of the microchannel. When we inject calcium chloride solution (cladding fluid) and deionized water (core fluid) into the inlet channels, the gradient refractive index (GRIN) developed in fluids flowing through the microchannel split the incident light beam into two beams with a larger split angle. Moreover, the designed inlets yield a GRIN distribution which increases the light collected around the middle horizontal line on the objective plane, and so enhances the transmission efficiency of the device. To demonstrate the performance of the proposed beam splitter, we use polydimethylsiloxane to fabricate the microchannel. The results obtained by simulation and experiment are compared to show the effectiveness of the device and the validity of numerical simulation. The influence of the microchannel geometry and the flow rate ratio on the performance of the proposed beam splitter is investigated.