Background: The pandemic condition felt by all parts of the world due to the very fast spread of COVID-19 threatens the safety of various health care sectors. Until now, the pandemic has been going on and has given rise to various new variants of COVID-19. Dental and oral health services are not spared from this, this condition is exacerbated by the fact that the virus spreads more easily through aerosols produced during treatment, especially by endodontists. Therefore, the researcher wanted to know the effect of knowledge and perception of endodontic risk on the control of COVID-19. Metods: This study uses an analytical descriptive research design with a cross-sectional study approach. Samples were obtained from all endodontists registered with IKORGI and completed filling out the questionnaire to completion. Questionnaires were distributed online via google forms. The research was carried out in November 2021. Result: Based on the results of research conducted on endodontists throughout Indonesia, it was found that the difference in perception on criterion control was sufficient with a mean value of 9.84 and a median value of 10.0, the difference in knowledge on criterion control was sufficient with a mean value of 6.99 and a median value of 7.0.