Phenotypic analysis showed that all laboratory parameters are lower in genetically confirmed VWD 2N patients compared with heterozygous 2N carriers. The clinical phenotype in genetically confirmed VWD 2N patients is comparable to mild haemophilia A patients and more severe than heterozygous 2N carriers.

- The aim of this review is to analyse the scientific literature in order to individuate the psychological aspects that have been studied concerning the impact of the Lipodystrophy syndrome, a symptomatic manifestation associated with antiretroviral therapy (HAART) for the treatment of HIV/AIDS infected patients. Three are the main guidelines emerging from the literature, respectively interested in the relations connecting lipodystrophy with the adherence to antiretroviral therapy, with the Quality of Life, and with the perceptions-evaluations of body changes. The results of the researches conducted in these three areas not always achieved consistent results, indicating the need for further investigations.