Pyoderma gangrenosum (PG) is an auto inflammatory non-infectious neutrophilic dermatosis often presenting with pustules or nodules that progress to ulcers. PG has specific clinical features and noncharacteristic histology findings. Some systemic diseases such as Crohn's disease, ulcerative colitis, rheumatoid arthritis, hematologic malignancy or autoimmune disease are commonly associated with PG. One of the most characteristic features of pyoderma gangrenosum is pathergy, which is the appearance of new lesions at sites of trauma, including surgical wounds.We present a 62-year-old male with a large ulceration on the left lower leg after a bee sting.
Carcinoma erysipeloides (CE) is an uncommon cutaneous metastasis of advanced breast carcinoma, showing distinctive features and presenting as a well-demarcated erythematous macule or plaque varying in size. It also may show a raised border and oedema. The differential diagnoses include erysipelas or cellulitis of the breast, or rarely-radiodermatitis. Most of the time CE is associated with advanced breast cancer and rarely with neoplastic tumours of the colon, pancreas, oesophagus, uterus, etc. We report a 58-year-old woman who presented at the Medical Institute of the Ministry of Internal Affairs with a 1-month history of not well-demarcated, erythematous, oedematous patches and plaques on the left and right breast, abdomen and both shins, associated with advanced invasive lobular carcinoma of the breast.
Disseminated superficial actinic porokeratosis (DSAP) is a skin condition that consist of multiple annular, hyperkeratotic lesions. They are usually distributed bilaterally and mostly affect the extremities. DSAPs have a wider distribution than the porokeratosis of Mibelli and usually appears between the age of 40 and 50. Squamous cell carcinoma, Bowen's disease, and basal cell carcinoma that arises in the classical type of porokeratosis of Mibelli is well-documented, but there are not many reported cases of Bowen's disease and basal cell carcinoma arising in DSAP. We present a 77-year-old woman in whom the two-Bowen's disease and Basal cell carcinoma develop in a histologically proven DSAP.
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