REPORT OF CASEClinical Histo9 :-The patient, a 15 year-old girl, was admitted to the Nihon University Hospital on June 27, 1956, complaining of weakness, fever, tachycardia, ecchymoses in skin, precordial discomfort and dyspnoea. There was a history of several episode of sudden onset of pain on fingers and toes during the previous 7 months and treated under rhe diagnosis of Raynaud's disease.On admission the 'patient was found emaciated, pallor and puffiness of the face was distinguished.Laborator_y fiedings of admission were as follows :-RBC 2,530,000 ; WBC 3800 ;