Redoxセンサータンパク質， ヘム制御ホスホジエスエラーゼの構造と機能 東北大学多元物質科学研究所 黒河博文，吉村-鈴木登紀子，笹倉由貴江，渡部美紀 平田智士，田口須恵，五十嵐城太郎，佐上郁子，清水 透Heme-regulated phosphodiesterase from Escherichia coli (Ec DOS) is a novel PAS heme-sensor enzyme. Ec DOS is active in the Fe 2+ heme-bound form, whereas it is inactive in the Fe 3+ heme-bound form. To elucidate the mechanism of the redox-dependent heme-regulated catalysis, we examined spectroscopic and functional characters of site-directed and deletion mutant proteins. We also determined crystal structures of the wild type enzyme under various conditions. In this review, we summarized findings about hemesensor proteins, PAS domain and phosphodiesterase in general and structure and function relationships of Ec DOS specifically. .(カラー図は電子ジャーナ ル参照)