In this paper, scientific research has been conducted on the production of fluoride disinfectants based on local raw materials in order to neutralize fluorine-contaminated soils in the vicinity of industrial enterprises. At the same time, the processes of fluoride ion binding of environmentally safe, biologically active drugs obtained on the basis of various bentonites, humic substances and chemically and physically modified bentonites were carried out in 0.1 normal sodium fluoride solution. Interaction of fluoride ion in fluoride solution with bentonite samples, oxidized charcoal, humic acid extracted from oxidized charcoal and humic calcium was studied in a wide range (100: 1 to 100:10) of the ratios of fluoride solution and the mentioned drugs.