HE PREVALENCE OF EXTREMEobesity in the United States is increasing at a rate greater than moderate obesity. 1 , 2 Unfortunately, lifestyle therapy is generally insufficient as a weight management intervention for patients who are extremely obese. To date, effective long-term weight loss through pharmacological therapy has been marginal, leaving bariatric For editorial comment see p 1160.

Disclosure StatementThis is not an industry supported study. Drs. Walker, Farney, Rhondeau, Cloward, Shilling, Ms. Boyle and Ms. Valentine have indicated no financial conflicts of interest.

No abstract