In the Republic of North Macedonia, the production of wine is very well known, but in the markets, there is also a variety of imported wines. Therefore, the aim of our research was to examine the basic parameters which determine the quality of the wine. A total of 106 domestic and imported wines were included in this research. The basic chemical parameters for each of the samples were examined by using standard OIV methods. Verification of the methods was done by determining its accuracy, precision, repeatability and reproducibility using standard reference material and proficiency testing. Depending on the sugar content, wines were divided into 4 groups: dry, semi dry, semi-sweet and sweet wines. The highest alcohol content was observed in dry wines originating from all countries that were subject of this research (up to 13.54 vol %) and the lowest was observed in wines originating from Italy which are mostly used as dessert wines (5.07 vol %). The semi-dry wines originating from France showed the slightest value (min.12.18 mg/L free SO 2 and min.60.20 mg/L total SO 2 ), which corresponds to their high quality and price on the market. This research is of great interest for the needs of the market and the price of the wine, due to the wine quality standards under the law of Republic of North Macedonia.

Molecular methods have become non-replaceable for the improvement of food production and its control. The Department for Biochemistry and Genetic Engineering (DBGE) as a part of the Faculty of Agriculture Sciences and Food is a crucial entity using molecular techniques in different areas of agriculture and livestock production. DBGE is mainly dealing with marker assisted selection (MAS), evolutionary studies; determine the origin of food products; enzyme analysis in food processing; transcriptional and translational analyses; molecular detection of plant viruses; and GMO analysis. The target molecules were proteins, RNA and DNA. MAS is systematically applied in animal breeding in Macedonia using RYR-1,  and S1-casein genes. Evolutionary studies were performed using DNA microsatellites to estimate genetic distance among autochthonic strains of sheep and tomato varieties. The identification of food products origin and gender identification in fish were done using protein profiling. Gene expression was studied analysing different growth factors and inhibitors at RNA level. More than 3.000 plant and animal samples were analysed in the Laboratory for biochemistry and molecular biology. GMO laboratory as a part of the DBGE is the first authorized facility for GMO testing of food and feed samples. In more than 100 samples RT PCR methods were used.