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. AbstructThe differential diagnostic capacity of a multi-directional sensing catheter with intraluminal objects was evaluated by fluorescence analysis following administration of a photosensitizer. The measurement catheter is 1.7 mm in diameter and is constructed with cross-sectional arrangement of 6 sensor bundle units and a centered guide wire lumen. Fluorescence was analyzed by polychrometer and amplified CCD camera with an image intensifier. The excitation light was 405nm wavelength obtained from an Xe-Hg lamp using a band pass filter. In vivo and in vitro fluorescence analysis of normal and atherosclerotic rabbit aorta was performed following intravenous administration of 5 mg/kg Hematoporphyrin Derivatives (HpD) 24 hours before. The diagnostic algorithm was based on the spectrum profile, a peak at 405nm and Plaque Index (PI=[F1630-(O.76F1600-i-O.24F1725)] /F1600) was identified for the fluorescence spectrum detected by each one of sensing units. Blood and fresh thrombus showed a flat profile without a 405nm peak (sens.=83.3%, spec.=100%). The normal arterial wall was PI O.15 with a 405nm peak. Intima of less than 200p.m was O.15

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