3C10 could control acute rejection by its suppressive effect on alloreactive T cells and induction of IL-10-dependent regulatory CD4 T cells.

No abstract

We present an experience with axillary artery and transapical aortic cannulation for cardiopulmonary bypass according to our indication. We could simply achieve antegrade flow using the two methods with satisfactory result.

Objective: Hypersensitive aesthesia for coldness is known to occur more frequent in women. We hypothesized that it is derived from sex difference of vascular response to coldness. In order to confirm this hypothesis, we examined the arterial response to cold exposure in rat hindlimbs. Methods: Male (M), female (F) and ovariectomized (OVX) Wistar rats were used. Cold exposure was induced by cooling spray on the hindlimb. Tissue temperature was recorded using digital thermometer after cold exposure. Synchrotron radiation microangiography (SRA) with a resolution of 26 um was employed for the measurement of arterial diameter. Timing of imaging was pre and one minute after cold exposure. Results: The reduction in temperature was significant in F and OVX compared with M (p<0.01). SRA showed that arteries of hindlimbs are dilated by cold exposure in all groups. Percentage of arterial dilatation in response to cold exposure was statistically small in F compared with M and OVX (69+/−40% (F), 118+/−73% (M), 99+/−42% (OVX), p < 0.05 vs F, respectively). Conclusion: Although it has been recognized that cutaneous vessels are constricted by cold exposure, the reaction of deep vessels of lower limbs were not investigated in association with gender difference. From this experiment, it is clarified that female arteries are less expansive, and existence of ovarian hormones disturbed the dilation of arteries against cold exposure.

ince the brain is sensitive to ischemia-reperfusion injury, management of acute aortic dissection with cerebral infarction is controversial. 1 We report on 4 patients with acute aortic dissection complicated by cerebral infarction.