Urinary excretion of human liver-type fatty acid-binding protein (hL-FABP

Preprandial administration provided a more stable absorption profile of cyclosporine compared with postprandial administration. From the correlation with AUC 0-4 , we concluded that C 2 , and not C 0 , is a reliable marker for monitoring cyclosporine exposure.

Although it is known that diabetic nephropathy is accelerated by hypertension, the mechanisms involved in this process are not clear. In this study we aimed to clarify these mechanisms using male Wistar fatty rats (WFR) as a type 2 diabetic model and male Wistar lean rats (WLR) as a control. Each group was fed a normal or high sodium diet from the age of 6 to 14 weeks. We determined the blood pressure and urinary albumin changes in the kidney, including glomerular hyperfiltration and glomerular hypertension (1). These changes are accompanied by structural changes such as glomerular hypertrophy, basement-membrane thickening or mesangial expansion (2). Accumulating evidence suggests that the metabolic pathway associated with hyperglycemia plays a pivotal role in the pathogenesis of diabetic nephropathy in part via the en-

There was an imbalance between .OH-producing ability and .OH-scavenging activity, in the ESRD patients, and this may be responsible for compromising the health of ESRD patients.

No abstract