Structured AbstractObjectivesTo develop a clinical practice guideline (CPG) for orthodontic retention (OR).Materials and MethodsThe CPG was developed according to the AGREE II instrument and EBRO (Dutch methodology for evidence‐based guideline development). Reporting was done according the RIGHT statement. A Task Force developed clinical questions regarding OR. To answer these questions, a systematic literature search in PubMed and EMBASE was performed. Two independent researchers identified and selected studies, assessed risk of bias using Cochrane RoB tool and rated quality of evidence using GRADE. The Task Force formulated considerations and recommendations after discussing the evidence. The concept CPG was sent for commentary to all relevant stakeholders.ResultOne systematic review—with 15 studies—met the inclusion criteria. In case of low evidence and lack of outcome measures, expert‐based considerations were developed. Over four meetings, the Task Force reached consensus on considerations and recommendations, after which the concept CPG was ready for the commentary phase. After processing the comments, the CPG was presented to the Dutch Association of Orthodontists, whereafter authorization followed.LimitationsThe paucity of evidence‐based studies concerning OR and the reporting of measurable patient outcomes.ConclusionThis CPG offers practitioner recommendations for best practice regarding OR, may reduce variation between practices and assists with patient aftercare. A carefully chosen retention procedure for individual patients, combined with clear information and communication between orthodontist, dentist and patient will contribute to long‐term maintenance of orthodontic treatment results.