Apo E2 (Arg25Cys) Kyoto is a novel mutation of apo E that is etiologically related to LPG. However, our case indicates that the development of LPG may involve other genetic or environmental factors. Furthermore, our data suggest that arginine-25 of apo E plays an important functional role by influencing the receptor-binding ability of apo E.

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The diasterofacial selectivity in the reaction of crotyl organometallic compounds (4) (M = Li+, Mg, B, and Sn) with imines (3) is investigated. The reaction of ordinary imines produces the erythro isomer (5) predominantly regardless of the metal (M). With increase of the steric bulk of the R group or with aryl substituent in the R' group, the threo isomer (6) predominates in the reaction of crotyl-9-BBN. The ratio of erythro (ll)/threo (12) in the reaction of pent-3-en-2-yl-9-BBN (9) is higher than the ratio of erythro (5)Ithreo (6) in the reaction of crotyl-9-BBN itself. On the basis of these observations, the transition-state geometry is discussed.

PC-904, sodium 6-{ d (−)-α-(4-hydroxy-1,5-naphthyridine-3-carboxamido) phenylacetamido}-penicillanate, is a novel semisynthetic penicillin derivative that possesses a broad spectrum of in vitro and in vivo antibacterial activities. In low concentrations, PC-904 inhibits growth against large proportions of the gram-positive and gram-negative organisms susceptible to carbenicillin and gentamicin. In addition, PC-904 is several times more potent than carbenicillin against organisms such as Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Proteus vulgaris, Shigella, Salmonella, Neisseria gonorrhoeae , and Bacteroides fragilis . Most striking are the inhibitory effects of PC-904 against P. aeruginosa and K. pneumoniae . Against these two clinical isolates, PC-904 is, respectively, 35 and 100 times more active than carbenicillin. The minimum inhibitory concentrations of PC-904 against P. aeruginosa are comparable to those of gentamicin. PC-904 acts bactericidally. The effect of inoculum size on the antibacterial activity is often small and generally comparable to carbenicillin. The rate of binding to serum protein is high (88 to 98%), but the effect of the addition of serum on the drug's activity is not marked, because such binding is reversible. It is confirmed that PC-904 has a very potent in vivo antibacterial activity against gram-negative and gram-positive organisms. Against systemic infections with P. aeruginosa, K. pneumoniae , and E. coli in mice, PC-904 is 7 to 10 times, over 8 times, and 2 to 15 times more active than carbenicillin, respectively.