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The existence ofatransendothelial channel ， which is considered to be involved in specific transport ofmacromolecules is reported ． In this study ， the generation mechanism ofvascular endothelial chained vesicles and the transendothelial channel is theoretically investigated based on minimization of bending and in − plane shear strain energy of the membrane ． A system of noniinear differential equations is derived aecerding to the variational principle and is reduced to a two point bounda【 y va 艮 ue problem ． SimuEated transertdothelial channel changes its shape dramatieally forrn chained vesicular channel te infUndibular channel depending on lower epening radius ．