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We investigated the e¡ect of testosterone (T) on tumor necrosis factor-K K (TNF-K K)-induced expression of vascular cell adhesion molecule-1 (VCAM-1) in human aortic endothelial cells. Incubation of these cells with T resulted in a dose-dependent reduction in the expression, with this reduction completely abolished by a selective androgen receptor blocker. Electrophoretic mobility shift assay demonstrated that T inhibited TNF-K Kinduced activation of the transcriptional nuclear factor-U UB, which is critical for the inducible expression of VCAM-1, probably through the suppression of the nuclear translocation. Our results may suggest an inhibitory e¡ect of T on atherogenesis, providing a novel insight into the consideration of the pathogenesis of atherosclerosis.

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